![]() In addition, aberrant DNA methylation patterns have been observed in many humanmalignancies and can also be used to define the severity of leukemia subtypes. Specifically, cytosine methylation can directly hinder binding of transcription factorsand methylated bases can also be bound by methyl-binding-domain proteins that recruitchromatin-remodeling factors. DNA methylation is one of the many epigenetic control mechanisms associated with generegulation. Specifically, cytosine methylation is a widespread modification in the genome, and itmost often occurs in CpG dinucleotides, although non-CpG cytosines are also methylated in certaintissues such as embryonic stem cells. DNA methylation is a critical epigenetic modification that guides development, cellulardifferentiation and the manifestation of some cancers.
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